It is quite easy to get rid of bacterial and viral infection, but fungal infection is hardest to deal particularly toe infection case by fungal growth. Although in some cases (late diagnosis and improper treatment) results in surgical extraction of effective nails and sometimes extirpation of fingers with nails. Onychomycosis is widely believed to be only a cosmetic problem, but it can be uncomfortable and can lead to cellulitis in older adults and foot ulcers in patients with diabetes. Eradication of the infection is key to improving appearance and avoiding these complications, but it is not easily accomplished because nails are made of keratin, which is nonvascular and impermeable to many agents. Because of poor drug delivery to nails, results of treatment may not be apparent for several years.